Evaluation of the index of resistance and excretion of uromodulin in patients with predialysis chronic kidney disease, taking into account the index of comorbidity

Background. The purpose of this study was to investigate urinary uromodulin (uUmod) excretion, reactivity the autonomic nervous system and impaired renal blood circulation in patients with predialysis chronic kidney disease (CKD), effect antioxidant therapy on these parameters. Materials methods. Ninety-one CKD stage 1–5 took part ROLUNT (UROmoduLin UbiquinoNe GlutaThione) study, their average age 47.00 ± 12.12 years. Thirty (32.97 %) men 61 (67.03 women were divided into two groups, which representative terms gender composition: first one (n = 46) — stage1–5 who had Charlson Comorbidity Index ≤ 2, second 45) ≥ 3. groups subgroups A B. Subgroup included vegetative status, subgroup B without status. Subgroups 1A 2B glutathione 100 mg twice a day food for 3 months; 1B 2A received ubiquinone once months. In stage1–5, uUmod, albumin creatinine ratio (ACR), glomerular filtration rate (GFR) evaluated. ultrasound duplex color scans kidneys performed index resistance (IR) determined stage1–5. Results. results paired t-test showed that there is significant difference between indicators at beginning end exception following: 1A: hemoglobin (Hb) (T –1.5863 [–2.0739, 2.0739] 95% confidence interval (CI) [–2.4077, 0.3207], p 0.127); 1B: Hb –0.382 2.0739], CI [–1.3977, 0.963], 0.706); ACR –1.5899 [–16.7323, 2.2105], 0.126); systolic pressure (SBP) –0.5625 [–2.2414, 1.2849], 0.579); diastolic (DBP) –1.7936 [–2.3437, 0.1698], 0.087); Chernov questionnaire 1.5071 [–0.6083, 3.8431], 0.146); Kérdö 0.9392 [–1.1083, 2.9431], 0.358); 2A: –2.0147 [–2.0796, 2.0796], [–39.1946, 0.6219], 0.057); 2B: –1.3328 [–17.4695, 3.7999], 0.196). Pearson correlation 1A, positive relationship uUmod eGFR (r(21) 0.418, 0.047); very small negative 0.438, 0.037); 1B, large 0.513, 0.012); Morisky Medication Adherence Scale-8 (MMAS-8) 0.515, 0.441, 0.035); 2A, (r(20) 0.427, 0.048); 2B, score 0.421, 0.045); 0.481, 0.020); 0.471, 0.023). following independent variables are not as predictors uUmod: IRd, IRs, SBP, DBP, Hb, ACR, age, Vein questionnaires score, MMAS-8, index. eGFR, Index. ­MMAS-8, Conclusions. Antioxidant significantly affects examination parameters CKD. Considering safety effectiveness therapy, we suggest including treatment protocols Further research recommended establish standard protocol.